abstract：:Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for testing various immunological hypotheses, but progress on this research ...

journal_title：Immunologic research

authors： Halemano K,Harper MS,Guo K,Li SX,Heilman KJ,Barrett BS,Santiago ML

更新日期：2013-03-01 00:00:00

abstract：:Systemic lupus erythematosus is a severe autoimmune disease that affects multiple organ systems resulting in diverse symptoms and outcomes. It is characterized by antibody production to a variety of self-antigens, but it is specifically associated with those against anti-dsDNA. Anti-dsDNA antibodies are present before...

journal_title：Immunologic research

authors： Giles BM,Boackle SA

更新日期：2013-03-01 00:00:00

abstract：:The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung diseas...

journal_title：Immunologic research

authors： Packard TA,Li QZ,Cosgrove GP,Bowler RP,Cambier JC

更新日期：2013-03-01 00:00:00

abstract：:Soybeans are rich in immuno-modulatory isoflavones such as genistein, daidzein, and glycitein. These isoflavones are well-known antioxidants, chemopreventive and anti-inflammatory agents. Several epidemiological studies suggest that consumption of traditional soy food containing isoflavones is associated with reduced ...

journal_title：Immunologic research

authors： Masilamani M,Wei J,Sampson HA

更新日期：2012-12-01 00:00:00

abstract：:During thymocyte development bone marrow-derived precursors in the thymus undergo a series of differentiation steps to produce self-tolerant, mature T lymphocytes. The thymus contains two functionally distinct anatomical compartments, consisting of a centrally located medulla surrounded by the thymic cortex. These com...

journal_title：Immunologic research

authors： Alexandropoulos K,Danzl NM

更新日期：2012-12-01 00:00:00

abstract：:Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung struct...

journal_title：Immunologic research

authors： Ramakrishna L,de Vries VC,Curotto de Lafaille MA

更新日期：2012-09-01 00:00:00

abstract：:Pathologies attributable to fungal infections represent a growing concern in both developed and developing countries. Initially discovered as opportunistic pathogens of immunocompromised hosts, fungi such as Candida albicans are now being placed at the centre of a more complex and dynamic picture in which the outcome ...

journal_title：Immunologic research

authors： Cottier F,Pavelka N

更新日期：2012-09-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine expressed mainly by epithelial cells. Current studies provide compelling evidence that TSLP is capable of activating dendritic cells to promote T helper (Th) 2 immune responses. TSLP has also been shown to directly promote Th2 differentiation of naï...

journal_title：Immunologic research

authors： Zhang Y,Zhou B

更新日期：2012-06-01 00:00:00

abstract：:Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increase...

journal_title：Immunologic research

authors： Draskovic-Pavlovic B,Vucevic D,Bozic B,Majstorovic I,Colic M

更新日期：2012-04-01 00:00:00

abstract：:It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis ...

journal_title：Immunologic research

authors： Krstic A,Mojsilovic S,Jovcic G,Bugarski D

更新日期：2012-04-01 00:00:00

abstract：:Chronic infections have been a major topic of investigation in recent years, but the mechanisms that dictate whether or not a pathogen is successfully controlled are incompletely understood. Cytomegalovirus (CMV) is a herpesvirus that establishes a persistent infection in the majority of people in the world. Like othe...

journal_title：Immunologic research

authors： Snyder CM

更新日期：2011-12-01 00:00:00

abstract：:For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. GUCY2C is expressed only in intestinal epithelial cells and by nearly 100% of colorectal cancers. We have developed and tested a recombinant adenoviral vector possessing GUCY2C...

journal_title：Immunologic research

authors： Snook AE,Magee MS,Waldman SA

更新日期：2011-12-01 00:00:00

abstract：:In the murine splenocytes, CD8α+ dendritic cells (abbreviated as 8+DC) and CD8α- dendritic cells (abbreviated as 8-DC) are identified with some vague features for each of them. 8+DCs but not 8-DCs cross-prime cytotoxic T cells in vivo. We aim to distinguish the two subtypes of DC based on gene expression profiling. Su...

journal_title：Immunologic research

authors： Li T,Li WY,Bai HL,Ma HB,Zhang H,Zhu JM,Li XH,Huang HY,Ma YF,Ji XY

更新日期：2011-10-01 00:00:00

abstract：:B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter antigen can further differentiate into antibody-secreting plasma cell...

journal_title：Immunologic research

authors： Santos P,Arumemi F,Park KS,Borghesi L,Milcarek C

更新日期：2011-08-01 00:00:00

abstract：:Previous studies by our group, using an experimental autoimmune thyroiditis (EAT) model in Strain 13 inbred guinea pigs, resulted in T cell-mediated delayed hypersensitivity; however, autoantibodies proved not to be cytotoxic to thyroid epithelial cells in the presence or absence of complement proteins. Albeit, T cell...

journal_title：Immunologic research

authors： Lin MS,Tse HM,Delmastro MM,Bertera S,Wong CT,Lakomy R,He J,Sklavos MM,Coudriet GM,Pietropaolo M,Trucco MM,Piganelli JD

更新日期：2011-08-01 00:00:00

abstract：:Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cells that are potently immunosuppressive and characteristic of CD8alpha-...

journal_title：Immunologic research

authors： Di Caro V,D'Anneo A,Phillips B,Engman C,Harnaha J,Trucco M,Giannoukakis N

更新日期：2011-08-01 00:00:00

abstract：:Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effec...

journal_title：Immunologic research

authors： Zhang P,Chen BJ,Chao NJ

更新日期：2011-04-01 00:00:00

abstract：:Immune cell development and function must be tightly regulated through cell surface receptors to ensure proper responses to pathogen and tolerance to self. In T cells, the signal from the T-cell receptor is essential for T-cell maturation, homeostasis, and activation. In mast cells, the high-affinity receptor for IgE ...

journal_title：Immunologic research

authors： Zhong XP,Shin J,Gorentla BK,O'Brien T,Srivatsan S,Xu L,Chen Y,Xie D,Pan H

更新日期：2011-04-01 00:00:00

abstract：:Recent research on hematological malignancies has shown that malignant cells often co-opt physiological pathways to promote their growth and development. Bone marrow homeostasis requires a fine balance between cellular differentiation and self-renewal; cell survival and apoptosis; and cellular proliferation and senesc...

journal_title：Immunologic research

authors： Chung E,Kondo M

更新日期：2011-04-01 00:00:00

abstract：:An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood...

journal_title：Immunologic research

authors： Briones MS,Chow SA

更新日期：2010-12-01 00:00:00

abstract：:Recent advances in molecular medicine have shown that soluble MHC-multimers can be valuable tools for both analysis and modulation of antigen-specific immune responses in vitro and in vivo. In this review, we describe the use of dimeric human and mouse major histocompatibility complexes, MHC-Ig, as part of an artifici...

journal_title：Immunologic research

authors： Oelke M,Schneck JP

更新日期：2010-07-01 00:00:00

abstract：:Considerable progress has been made in understanding the Fas pathway at the molecular and cellular levels, but fundamental questions about the overall biological role of the Fas pathway remain unresolved. A major question is why lymphoproliferation caused by the lpr mutation of Fas and gld mutation of FasL ligand (Fas...

journal_title：Immunologic research

authors： Hamad AR

更新日期：2010-07-01 00:00:00

abstract：:Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to stu...

journal_title：Immunologic research

authors： Wasowska BA

更新日期：2010-07-01 00:00:00

abstract：:The two-signal model of T cell activation states that antigen recognition by TCR provides a tolerogenic signal (termed Signal 1) unless the T cell receives simultaneous costimulation (Signal 2) that permits antigen recognition to prime activation. Our efforts to characterize genetic and biochemical factors resulting f...

journal_title：Immunologic research

authors： Gamper CJ,Powell JD

更新日期：2010-07-01 00:00:00

abstract：:The attributes of specificity and memory enable CD8(+) T cells to provide long-lasting protection against a variety of challenges. Although, the importance of CD8(+) T cells for protection against intracellular infections and transformation is well-established, the functional type; effector phenotypes (Tc1, Tc2, Tc17 ...

journal_title：Immunologic research

authors： Shrikant PA,Rao R,Li Q,Kesterson J,Eppolito C,Mischo A,Singhal P

更新日期：2010-03-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal anti-CD20 antibody and was the first monoclonal antibody (mAb) therapy approved by FDA (Food and Drug Administration) for the treatment of B-cell lymphoma. It has revolutionized the treatment of patients with CD20-positive non-Hodgkin's lymphoma and CLL. Rituximab is currently being ...

journal_title：Immunologic research

authors： Riaz W,Hernandez-Ilizaliturri FJ,Czuczman MS

更新日期：2010-03-01 00:00:00

abstract：:Besides their well-characterized role as the initiator of adaptive immune responses, dendritic cells (DCs) play a critical role in the induction and maintenance of self-tolerance, the failure of which could lead to autoimmune/inflammatory diseases. Although it is clear that tolerance is a property of DCs at the steady...

journal_title：Immunologic research

authors： Fu C,Jiang A

更新日期：2010-03-01 00:00:00

abstract：:There is increasing documentation of significant survival benefits achieved in cancer patients treated with hyperthermia in combination with radiation and/or chemotherapy. Most evidence collected regarding the mechanisms by which hyperthermia positively influences tumor control has centered on in vitro data showing th...

journal_title：Immunologic research

authors： Peer AJ,Grimm MJ,Zynda ER,Repasky EA

更新日期：2010-03-01 00:00:00

abstract：:Recent studies have elucidated unanticipated connections between the immune and skeletal systems, and this relationship has led to the development of a new field known as osteoimmunology. The goal of research in this field is to: (1) further understand how the bone microenvironment influences immune cell ontogeny and ...

journal_title：Immunologic research

authors： Mensah KA,Li J,Schwarz EM

更新日期：2009-12-01 00:00:00

abstract：:CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of prot...

journal_title：Immunologic research

authors： Livingstone AM,Wilson EB,Ontiveros F,Wang JC

更新日期：2009-12-01 00:00:00

abstract：:Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors-chemotaxis for chasing down infectious pathogens and phagocyto...

journal_title：Immunologic research

authors： Jin T,Xu X,Fang J,Isik N,Yan J,Brzostowski JA,Hereld D

更新日期：2009-01-01 00:00:00

abstract：:We report on 12 patients with chronic granulomatous disease transplanted with hematopoietic stem cells from matched unrelated (n = 9) or matched sibling donors (n = 3). The most common infectious complication was pulmonary aspergillosis, which nine patients had previously developed. Only 5 of 12 individuals had normal...

journal_title：Immunologic research

authors： Schuetz C,Hoenig M,Gatz S,Speth F,Benninghoff U,Schulz A,Debatin KM,Friedrich W

更新日期：2009-01-01 00:00:00

abstract：:Purified protein derivative (PPD) or tuberculin skin testing is used to identify infected individuals with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immunity to Mtb. In the present study, we compared PBMC cultures in the presence of tuberculin or Candida antigens using cytokine bead arrays and RNA m...

journal_title：Immunologic research

authors： Stern JN,Keskin DB,Romero V,Zuniga J,Encinales L,Li C,Awad C,Yunis EJ

更新日期：2009-01-01 00:00:00

abstract：:Mutations of the Wiskott-Aldrich Syndrome Protein (WASP) are responsible for classic Wiskott-Aldrich Syndrome (WAS), X-linked thrombocytopenia (XLT), and in rare instances congenital X-linked neutropenia (XLN). WASP is a regulator of actin polymerization in hematopoietic cells with well-defined functional domains that...

journal_title：Immunologic research

authors： Ochs HD

更新日期：2009-01-01 00:00:00

abstract：:We retrospectively analyzed the transplantation outcomes of 31 patients with primary immunodeficiency diseases treated at our center (All Children's Hospital, University of South Florida) since its inception in 1986. The primary immune diseases included severe combined immunodeficiency, Wiscott-Aldrich syndrome, X-lin...

journal_title：Immunologic research

authors： Petrovic A,Dorsey M,Miotke J,Shepherd C,Day N

更新日期：2009-01-01 00:00:00

abstract：:Current approaches for hematopoietic stem cell (HSC) and organ transplantation are limited by donor and host-mediated immune responses to allo-antigens. Application of these therapies is limited by the toxicity of preparative and post-transplant immunosuppressive regimens and a shortage of appropriate HLA-matched dono...

journal_title：Immunologic research

authors： Hacke K,Falahati R,Flebbe-Rehwaldt L,Kasahara N,Gaensler KM

更新日期：2009-01-01 00:00:00

abstract：:WASP, the product of the gene mutated in Wiskott-Aldrich syndrome, is expressed only in hematopoietic cells and is the archetype of a family of proteins that include N-WASP and Scar/WAVE. WASP plays a critical role in T cell activation and actin reorganization. WASP has multiple protein-interacting domains. Through it...

journal_title：Immunologic research

authors： Ramesh N,Geha R

更新日期：2009-01-01 00:00:00

abstract：:The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus, includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their emergence to new geogra...

journal_title：Immunologic research

authors： Robertson SJ,Mitzel DN,Taylor RT,Best SM,Bloom ME

更新日期：2009-01-01 00:00:00

abstract：:The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoi...

journal_title：Immunologic research

authors： Leung WH,Tarasenko T,Bolland S

更新日期：2009-01-01 00:00:00

abstract：:Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine (DA)-producing neurons in the brain. Production of inflammatory products by these microglial cells characterizes the slow destructive process in Parkinson's disease (PD). The activation of microglial cell...

journal_title：Immunologic research

authors： Qian L,Flood PM

更新日期：2008-01-01 00:00:00